Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis

Tauroursodeoxycholic acid ( TUDCA) prevents amyloid beta-peptide (A beta)-induced neuronal apoptosis, by modulating both classical mitochondrial pathways and specific upstream targets. In addition, activation of nuclear steroid receptors (NSRs), such as t

Detalhes bibliográficos
Autor principal: Sola, Susana (author)
Outros Autores: Amaral, Joana D. (author), Borralho, Pedro M. (author), Ramalho, Rita M. (author), Castro, Rui E. (author), Aranha, Marcia M. (author), Steer, Cifford J. (author), Rodrigues, Cecilia M. P. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Endocrinology & Metabolism
Texto completo:http://hdl.handle.net/10451/21085
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21085
Descrição
Resumo:Tauroursodeoxycholic acid ( TUDCA) prevents amyloid beta-peptide (A beta)-induced neuronal apoptosis, by modulating both classical mitochondrial pathways and specific upstream targets. In addition, activation of nuclear steroid receptors (NSRs), such as t

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