Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos

Left-right (L-R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is transmitted from the node to the lateral plate has remained unknown. We have now identified a transcriptional enhancer (ANE) in the human LEFTY1 gene...

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Bibliographic Details
Main Author: Kawasumi, Aiko (author)
Other Authors: Nakamura, Tetsuya (author), Iwai, Naomi (author), Yashiro, Kenta (author), Saijoh, Yukio (author), Belo, Jose Antonio (author), Shiratori, Hidetaka (author), Hamada, Hiroshi (author)
Format: article
Language:eng
Published: 2018
Subjects:
Left-right axis
Expression
Requires
Inhibition
Mutation
Genes
Mice
Online Access:http://hdl.handle.net/10400.1/11730
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11730

Internet

http://hdl.handle.net/10400.1/11730

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