Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity

Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and...

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Detalhes bibliográficos
Autor principal: Arts, Rob J.W. (author)
Outros Autores: Novakovic, Boris (author), ter Horst, Rob (author), Carvalho, Agostinho Albérico Rodrigues (author), Bekkering, Siroon (author), Lachmandas, Ekta (author), Rodrigues, Fernando José dos Santos (author), Silvestre, Ricardo Jorge Leal (author), Cheng, Shih Chin (author), Wang, Shuang Yin (author), Gonçalves, Luís G. (author), Mesquita, Inês (author), Cunha, Cristina (author), van Laarhoven, Arjan (author), van de Veerdonk, Frank L. (author), Williams, David L. (author), van der Meer, Jos W.M. (author), Logie, Colin (author), O'Neill, Luke A. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Epigenetics
Glutamine metabolism
Cholesterol metabolism
Glycolysis
Trained immunity
Ciências Médicas::Medicina Básica
Science & Technology
Texto completo:http://hdl.handle.net/1822/44939
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/44939

Texto Completo

http://hdl.handle.net/1822/44939

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