Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity

Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and...

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Bibliographic Details
Main Author: Arts, Rob J.W. (author)
Other Authors: Novakovic, Boris (author), ter Horst, Rob (author), Carvalho, Agostinho Albérico Rodrigues (author), Bekkering, Siroon (author), Lachmandas, Ekta (author), Rodrigues, Fernando José dos Santos (author), Silvestre, Ricardo Jorge Leal (author), Cheng, Shih Chin (author), Wang, Shuang Yin (author), Gonçalves, Luís G. (author), Mesquita, Inês (author), Cunha, Cristina (author), van Laarhoven, Arjan (author), van de Veerdonk, Frank L. (author), Williams, David L. (author), van der Meer, Jos W.M. (author), Logie, Colin (author), O'Neill, Luke A. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Epigenetics
Glutamine metabolism
Cholesterol metabolism
Glycolysis
Trained immunity
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/44939
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/44939

Internet

http://hdl.handle.net/1822/44939

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