Insights into the protective role of solid lipid nanoparticles on rosmarinic acid bioactivity during exposure to simulated gastrointestinal conditions

The evaluation of the digestion effects on bioactive solid lipid nanoparticles (SLN) was performed. For this purpose, witepsol and carnauba SLN loaded with rosmarinic acid (RA) were exposed to the simulated gastrointestinal tract (GIT) conditions prevailing in stomach and small intestine. The simula...

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Bibliographic Details
Main Author: Madureira, Ana Raquel (author)
Other Authors: Campos, Débora A. (author), Oliveira, Ana L. (author), Sarmento, Bruno (author), Pintado, M. E. (author), Gomes, Ana M. P. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Antioxidants
Biomimetic Materials
Caco-2 Cells
Cinnamates
Delayed-Action Preparations
Depsides
Dialysis
Drug Compounding
Drug Liberation
Gastric Juice
HT29 Cells
Humans
Hydrogen-Ion Concentration
Intestinal Absorption
Intestine, Small
Models, Biological
Nanoparticles
Pancreatin
Particle Size
Pepsin A
Stomach
Triglycerides
Waxes
Online Access:http://hdl.handle.net/10400.14/23142
Country:Portugal
Oai:oai:repositorio.ucp.pt:10400.14/23142

Internet

http://hdl.handle.net/10400.14/23142

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