Artemisinin resistance in rodent malaria - Mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Background: The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that art...

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Bibliographic Details
Main Author: Henriques, Gisela (author)
Other Authors: Martinelli, Axel (author), Rodrigues, Louise (author), Modrzynska, Katarzyna (author), Fawcett, Richard (author), Houston, Douglas R. (author), Borges, Sofia T. (author), D'Alessandro, Umberto (author), Tinto, Halidou (author), Karema, Corine (author), Hunt, Paul (author), Cravo, Pedro (author)
Format: article
Language:eng
Published: 2021
Subjects:
Artemisinin
Drug resistance
Endocytic machinery
Genomics
Malaria
Mutation
Plasmodium chabaudi
Parasitology
Infectious Diseases
Genetics
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/117026
Country:Portugal
Oai:oai:run.unl.pt:10362/117026

Internet

http://hdl.handle.net/10362/117026

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