An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Prion (PrP) and amyloid-[beta] (A[beta]) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanism...

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Bibliographic Details
Main Author: Ferreiro, Elisabete (author)
Other Authors: Resende, Rosa (author), Costa, Rui (author), Oliveira, Catarina R. (author), Pereira, Cláudia M. F. (author)
Format: article
Language:eng
Published: 2006
Subjects:
Prion disorders
Alzheimer's disease
Prion peptide
Amyloid-β peptide
Apoptosis
Ca2+ homeostasis
Endoplasmic reticulum
Oxidative stress
Online Access:http://hdl.handle.net/10316/4738
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/4738

Internet

http://hdl.handle.net/10316/4738

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