α-Chymotrypsin catalyses the synthesis of methotrexate oligomers
The enzymatic synthesis of methotrexate (MTX) catalysed by ? -chymotrypsin was studied for the first time. The proteolytic enzyme displayed activity for the synthesis of MTX oligomers composed by 6 repeating units (DPavg?=?1.5). For longer oligomers, molecular dynamics simulations confirmed that as...
| Autor principal: | |
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| Outros Autores: | , , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2020
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| Assuntos: | |
| Texto completo: | http://hdl.handle.net/1822/67065 |
| País: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/67065 |