α-Chymotrypsin catalyses the synthesis of methotrexate oligomers

The enzymatic synthesis of methotrexate (MTX) catalysed by ? -chymotrypsin was studied for the first time. The proteolytic enzyme displayed activity for the synthesis of MTX oligomers composed by 6 repeating units (DPavg?=?1.5). For longer oligomers, molecular dynamics simulations confirmed that as...

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Bibliographic Details
Main Author: Noro, Jennifer Martins (author)
Other Authors: Castro, Tarsila Gabriel (author), Cavaco-Paulo, Artur (author), Silva, Carla (author)
Format: article
Language:eng
Published: 2020
Subjects:
a-chymotrypsin
Methotrexate
Dimers
Oligomers
Science & Technology
Online Access:http://hdl.handle.net/1822/67065
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67065

Internet

http://hdl.handle.net/1822/67065

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