The era of RNA interference medicines: the clinical landscape of synthetic gene silencing drugs

Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), provide a simple and effective tool to modulate the expression of any gene. siRNAs harness the RNA interference (RNAi) pathway to degrade disease-associated messenger RNAs (mRNAs). The inherent sequence specificity and potency of...

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Bibliographic Details
Main Author: Godinho, Bruno M. D. C. (author)
Other Authors: Khvorova, Anastasia (author)
Format: article
Language:por
Published: 2022
Subjects:
ARN interferência
siRNA
miRNA
Oligonucleotídios para terapêutica
Desenvolvimento de novos fármacos
RNA interference
Therapeutic oligonucleotides
Gene knockdown
Drug development
Online Access:https://doi.org/10.25758/set.2227
Country:Portugal
Oai:oai:journals.ipl.pt:article/536

Internet

https://doi.org/10.25758/set.2227

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