Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

Transthyretin (TTR) transports the retinol-binding protein-vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to become amyloidogenic. Mutations in the TTR gene general...

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Bibliographic Details
Main Author: Coelho, T. (author)
Other Authors: Merlini, G. (author), Bulawa, C. (author), Fleming, J. (author), Judge, D. (author), Kelly, J. (author), Maurer, M. (author), Planté-Bordeneuve, V. (author), Labaudinière, R. (author), Mundayat, R. (author), Riley, S. (author), Lombardo, I. (author), Huertas, P. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Familial amyloid cardiomyopathy
Familial amyloid polyneuropathy
Hereditary TTR amyloid cardiomyopathy
Pharmacology
Senile systemic amyloidosis
Therapeutic use
Wild-type TTR amyloidosis
Online Access:http://hdl.handle.net/10400.16/2141
Country:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2141

Internet

http://hdl.handle.net/10400.16/2141

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