Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes an irreversible, cumulative and dose-dependent cardiomyopathy that ultimately leads to congestive heart failure. The mechanisms responsible for DOX cardiotoxicity remain poorly understood, but seem to involve mitochondrial d...

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Detalhes bibliográficos
Autor principal: Ferreira, André (author)
Outros Autores: Cunha-Oliveira, Teresa (author), Simões, Rui F. (author), Carvalho, Filipa S. (author), Burgeiro, Ana (author), Nordgren, Kendra (author), Wallace, Kendall B. (author), Oliveira, Paulo J. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
5-Methylcytosine
Acetyl Coenzyme A
Acetylation
Animals
Cardiotoxicity
DNA, Mitochondrial
Disease Models, Animal
Heart Diseases
Histone Deacetylases
Lysine
Male
Mitochondria, Heart
Mitochondrial Proteins
Organelle Biogenesis
Protein Processing, Post-Translational
RNA, Messenger
Rats, Wistar
Transcription, Genetic
Antibiotics, Antineoplastic
DNA Methylation
Doxorubicin
Epigenesis, Genetic
Texto completo:http://hdl.handle.net/10316/44845
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/44845

Texto Completo

http://hdl.handle.net/10316/44845

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