Proteins multi-funnel energy landscape and misfolding diseases

The problem of how a given a-amino acid sequence, in cells, most of the times, assumes the native structure, is a fundamental problem in Biology, known as the protein folding problem. Here, evidence is presented that suggests that the same a-amino acid sequence can assume several, very different, st...

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Bibliographic Details
Main Author: Cruzeiro, Leonor (author)
Format: article
Language:eng
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10400.1/3543
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/3543