Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution.

Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs activate the spindle assembly checkpoint (SAC), which induces mitotic arrest and subsequent apoptosis. However, besides tox...

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Detalhes bibliográficos
Autor principal: Bousbaa, Hassan (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Antimitotics
Spindle assembly checkpoint
Mitotic blockers and drivers
Combination therapy
Apoptosis
Texto completo:http://hdl.handle.net/20.500.11816/2982
País:Portugal
Oai:oai:repositorio.cespu.pt:20.500.11816/2982

Texto Completo

http://hdl.handle.net/20.500.11816/2982

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