Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental...

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Bibliographic Details
Main Author: Paredes, João A. (author)
Other Authors: Carreto, Laura (author), Simões, João (author), Bezerra, Ana R. (author), Gomes, Ana C. (author), Santamaria, Rodrigo (author), Kapushesky, Misha (author), Moura, Gabriela R. (author), Santos, Manuel A. S. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Yeast
Mistranslation
tRNA
Protein synthesis
mRNA profiling
Stress
Proteotoxic stress
Protein misfolding
Unfolded protein response
Online Access:http://hdl.handle.net/10773/26946
Country:Portugal
Oai:oai:ria.ua.pt:10773/26946

Internet

http://hdl.handle.net/10773/26946

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