Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental...

ver descrição completa

Detalhes bibliográficos
Autor principal: Paredes, João A. (author)
Outros Autores: Carreto, Laura (author), Simões, João (author), Bezerra, Ana R. (author), Gomes, Ana C. (author), Santamaria, Rodrigo (author), Kapushesky, Misha (author), Moura, Gabriela R. (author), Santos, Manuel A. S. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Yeast
Mistranslation
tRNA
Protein synthesis
mRNA profiling
Stress
Proteotoxic stress
Protein misfolding
Unfolded protein response
Texto completo:http://hdl.handle.net/10773/26946
País:Portugal
Oai:oai:ria.ua.pt:10773/26946

Texto Completo

http://hdl.handle.net/10773/26946

Registos relacionados