Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol
Dipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 degrees C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the...
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| Other Authors: | , , , , |
| Format: | article |
| Language: | eng |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10216/82058 |
| Country: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/82058 |