Virtual screening of low molecular weight mushrooms compounds as potential Mdm2 inhibitors.
In some human cancer cases, the activity of p53 is inhibited by overexpressed Mdm2. Mdm2 acts as an ubiquitin ligase, resulting in p53 ubiquitination and subsequent p53 proteasomal degradation. The disruption of the Mdm2-p53 interaction using small-molecule inhibitors is recognized as a promising st...
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| Other Authors: | , |
| Format: | article |
| Language: | eng |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10198/8308 |
| Country: | Portugal |
| Oai: | oai:bibliotecadigital.ipb.pt:10198/8308 |