The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease

Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is the most common autosomal dominantly-inherited ataxia worldwide and is characterised by the accumulation of mutant ataxin-3 (mutATXN3) in different brain regions, leading to neurodegeneration. Currently, there are no available...

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Bibliographic Details
Main Author: Vasconcelos-Ferreira, Ana (author)
Other Authors: Carmo-Silva, Sara (author), Codêsso, José Miguel Antunes (author), Silva, Patrick Joel da (author), Martinez, Alberto Rolim Muro (author), França, Marcondes Cavalcante (author), Nóbrega, Clévio David Rodrigues (author), Almeida, Luís Pereira de (author)
Format: article
Language:eng
Published: 2021
Subjects:
Machado-Joseph disease
Ataxin-3
Autophagy
Carbamazepine
Neuroprotection
Online Access:http://hdl.handle.net/10316/96433
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/96433

Internet

http://hdl.handle.net/10316/96433

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