Transition from Cyclosporine-Induced Renal Dysfunction to Nephrotoxicity in an in Vivo Rat Model

Cyclosporin A (CsA), a calcineurin inhibitor, remain the cornerstone of immunosuppressive regimens, regardless of nephrotoxicity, which depends on the duration of drug exposure. The mechanisms and biomarkers underlying the transition from CsA-induced renal dysfunction to nephrotoxicity deserve bette...

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Bibliographic Details
Main Author: Sereno, José (author)
Other Authors: Rodrigues-Santos, Paulo (author), Vala, Helena (author), Rocha-Pereira, Petronila (author), Alves, Rui (author), Fernandes, João (author), Santos-Silva, Alice (author), Carvalho, Eugénia (author), Teixeira, Frederico (author), Reis, Flávio (author)
Format: article
Language:eng
Published: 2014
Subjects:
Cyclosporin A
transition from dysfunction to nephrotoxicity
biomarkers
fibrosis
proliferation
animal model
Online Access:http://hdl.handle.net/10400.19/2181
Country:Portugal
Oai:oai:repositorio.ipv.pt:10400.19/2181

Internet

http://hdl.handle.net/10400.19/2181

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