Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

The recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly fr...

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Bibliographic Details
Main Author: Alves, Sara (author)
Other Authors: Castro, Lisandra (author), Fernandes, Maria Sofia (author), Francisco, Rita (author), Castro, Paula (author), Priault, Muriel (author), Chaves, Susana Rodrigues (author), Moyer, Mary Pat (author), Oliveira, Carla (author), Seruca, Raquel (author), Côrte-Real, Manuela (author), Sousa, Maria João (author), Preto, Ana (author)
Format: article
Language:eng
Published: 2015
Subjects:
autophagy
KRAS mutations
colorectal cancer
humanized yeast
non-cancer colon cells
Science & Technology
Online Access:http://hdl.handle.net/1822/48486
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/48486

Internet

http://hdl.handle.net/1822/48486

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