Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

The recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly fr...

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Detalhes bibliográficos
Autor principal: Alves, Sara (author)
Outros Autores: Castro, Lisandra (author), Fernandes, Maria Sofia (author), Francisco, Rita (author), Castro, Paula (author), Priault, Muriel (author), Chaves, Susana Rodrigues (author), Moyer, Mary Pat (author), Oliveira, Carla (author), Seruca, Raquel (author), Côrte-Real, Manuela (author), Sousa, Maria João (author), Preto, Ana (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
autophagy
KRAS mutations
colorectal cancer
humanized yeast
non-cancer colon cells
Science & Technology
Texto completo:http://hdl.handle.net/1822/48486
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/48486

Texto Completo

http://hdl.handle.net/1822/48486

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