Model-guided development of an evolutionarily stable yeast chassis

Abstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Sa...

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Detalhes bibliográficos
Autor principal: Pereira, Filipa (author)
Outros Autores: Lopes, Hélder (author), Maia, Paulo (author), Meyer, Britta (author), Nocon, Justyna (author), Jouhten, Paula (author), Konstantinidis, Dimitrios (author), Kafkia, Eleni (author), Rocha, Miguel (author), Kötter, Peter (author), Rocha, I. (author), Patil, Kiran R (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Adaptive laboratory evolution
Chassis cell
Metabolic engineering
Multi-objective optimization
Systems biology
Science & Technology
Texto completo:http://hdl.handle.net/1822/73774
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73774

Texto Completo

http://hdl.handle.net/1822/73774

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