Model-guided development of an evolutionarily stable yeast chassis

Abstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Sa...

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Bibliographic Details
Main Author: Pereira, Filipa (author)
Other Authors: Lopes, Hélder (author), Maia, Paulo (author), Meyer, Britta (author), Nocon, Justyna (author), Jouhten, Paula (author), Konstantinidis, Dimitrios (author), Kafkia, Eleni (author), Rocha, Miguel (author), Kötter, Peter (author), Rocha, I. (author), Patil, Kiran R (author)
Format: article
Language:eng
Published: 2021
Subjects:
Adaptive laboratory evolution
Chassis cell
Metabolic engineering
Multi-objective optimization
Systems biology
Science & Technology
Online Access:http://hdl.handle.net/1822/73774
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73774

Internet

http://hdl.handle.net/1822/73774

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