Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation

Mitotic spindle orientation is essential to control cell-fate specification and epithelial architecture. The tumor suppressor Lgl localizes to the basolateral cortex of epithelial cells, where it acts together with Dlg and Scrib to organize apicobasal polarity. Dlg and Scrib also control planar spin...

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Bibliographic Details
Main Author: Carvalho, CA (author)
Other Authors: Moreira, S (author), Ventura, G (author), Sunkel, CE (author), Morais-de-Sá, E (author)
Format: article
Language:eng
Published: 2015
Subjects:
Animals
Aurora Kinase A/metabolism
Cell Division
Cell Polarity
Drosophila
Drosophila Proteins/metabolism
Epithelial Cells/physiology
Guanine Nucleotide Dissociation Inhibitors/metabolism
Protein Kinase C/metabolism
Spindle Apparatus/physiology
Tumor Suppressor Proteins/metabolism
Online Access:http://hdl.handle.net/10216/110356
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110356

Internet

http://hdl.handle.net/10216/110356

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