Valproate induces in vitro accumulation of long-chain fatty acylcarnitines

To elucidate the interference mechanisms of valproate (VPA) with mitochondrial fatty acid beta -oxidation (FAO), the profile of acylcarnitine formation was studied in vitro. Human fibroblasts were incubated with 0.2 mmol/L [U-C-13]palmitate, 0.4 mmol/L L-

Bibliographic Details
Main Author: Silva, MFB (author)
Other Authors: Jakobs, C (author), Duran, M (author), de Almeida, IT (author), Wanders, RJA (author)
Format: article
Language:eng
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10451/21330
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21330