Double optimization of rivastigmine-loaded Nanostructured Lipid Carriers (NLC) for nose-to-brain delivery using the Quality by Design (QbD) approach: formulation variables and instrumental parameters

Rivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double...

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Bibliographic Details
Main Author: Cunha, Sara (author)
Other Authors: Costa, Cláudia Pina (author), Loureiro, Joana A. (author), Alves, Jorge (author), Peixoto, Andreia F. (author), Forbes, Ben (author), Sousa Lobo, José Manuel (author), Silva, Ana Catarina (author)
Format: article
Language:eng
Published: 2021
Subjects:
Nanostructured Lipid Carriers (NLC)
Formulation optimization
Rivastigmine
Quality by Design (QbD)
Nasal route
Nose-to-brain
Online Access:http://hdl.handle.net/10284/9815
Country:Portugal
Oai:oai:bdigital.ufp.pt:10284/9815

Internet

http://hdl.handle.net/10284/9815

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