Double optimization of rivastigmine-loaded Nanostructured Lipid Carriers (NLC) for nose-to-brain delivery using the Quality by Design (QbD) approach: formulation variables and instrumental parameters

Rivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double...

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Detalhes bibliográficos
Autor principal: Cunha, Sara (author)
Outros Autores: Costa, Cláudia Pina (author), Loureiro, Joana A. (author), Alves, Jorge (author), Peixoto, Andreia F. (author), Forbes, Ben (author), Sousa Lobo, José Manuel (author), Silva, Ana Catarina (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Nanostructured Lipid Carriers (NLC)
Formulation optimization
Rivastigmine
Quality by Design (QbD)
Nasal route
Nose-to-brain
Texto completo:http://hdl.handle.net/10284/9815
País:Portugal
Oai:oai:bdigital.ufp.pt:10284/9815

Texto Completo

http://hdl.handle.net/10284/9815

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