An integrative system biology approach to delineate complex genotype-phenotype associations in Autism Spectrum Disorder

Objectives: The global objective of the study is to improve the current knowledge on ASD prognosis and diagnosis by delineating the complex genotype-phenotype associations using an integrative systems biology approach. For this purpose three specific objectives were pursued: - To identify clinically...

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Bibliographic Details
Main Author: Asif, M. (author)
Other Authors: Martiniano, Hugo F. (author), Rasga, Célia (author), Marques, Ana R. (author), Santos, João X. (author), Couto, Francisco M. (author), Vicente, Astrid M. (author)
Format: conferenceObject
Language:eng
Published: 2017
Subjects:
Autism Spectrum Disorder
Perturbações do Desenvolvimento Infantil e Saúde Mental
Autismo
Online Access:http://hdl.handle.net/10400.18/4851
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/4851
Description
Summary:Objectives: The global objective of the study is to improve the current knowledge on ASD prognosis and diagnosis by delineating the complex genotype-phenotype associations using an integrative systems biology approach. For this purpose three specific objectives were pursued: - To identify clinically similar subgroups of individuals with ASD; - To find biological processes disrupted by rare CNVs targeting brain genes in ASD subjects; - To train a machine learning classifier for the clinical prediction of disease progression from genetic information in very young children.

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