Targeting lactate transport suppresses in vivo breast tumour growth.

BACKGROUND Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as "Warburg effect". Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated w...

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Detalhes bibliográficos
Autor principal: Moreira, António Herculano Jesus (author)
Outros Autores: Pinheiro, Céline (author), Baltazar, Fátima (author), Vilaça, João L. (author), Longatto Filho, Adhemar (author), Santos, Luísa Filipa Morais dos (author), Queirós, Sandro Filipe Monteiro (author), Granja, Sara Costa (author), Gonçalves, Vera M. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Monocarboxylate transporters
Breast carcinoma
Hypoxia
Lactate
Warburg effect
Science & Technology
Texto completo:http://hdl.handle.net/1822/40324
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40324

Texto Completo

http://hdl.handle.net/1822/40324

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