Targeting lactate transport suppresses in vivo breast tumour growth.

BACKGROUND Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as "Warburg effect". Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated w...

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Bibliographic Details
Main Author: Moreira, António Herculano Jesus (author)
Other Authors: Pinheiro, Céline (author), Baltazar, Fátima (author), Vilaça, João L. (author), Longatto Filho, Adhemar (author), Santos, Luísa Filipa Morais dos (author), Queirós, Sandro Filipe Monteiro (author), Granja, Sara Costa (author), Gonçalves, Vera M. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Monocarboxylate transporters
Breast carcinoma
Hypoxia
Lactate
Warburg effect
Science & Technology
Online Access:http://hdl.handle.net/1822/40324
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40324

Internet

http://hdl.handle.net/1822/40324

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