Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus were synthesized and evaluated as potential transmission-blocking antimalarial prodrugs. All compounds were hydrolyzed to the parent dipeptide derivative of primaquine in neutral and basic solutions, with half li...

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Bibliographic Details
Main Author: Nuno Vale (author)
Other Authors: Fatima Nogueira (author), Virgilio E do Rosario (author), Paula Gomes (author), Rui Moreira (author)
Format: article
Language:eng
Published: 2009
Subjects:
Online Access:https://hdl.handle.net/10216/82093
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/82093