Overactivation of calcineurin induced by amyloid-beta and prion proteins

Amyloid-beta protein (A[beta]) and the scrapie isoform of prion protein (PrPSs) have a central role in the pathogenesis of Alzheimer's disease (AD) and prion-related encephalopathies (PRE), respectively. In both disorders, the deposition of these misfolded proteins is accompanied by apoptotic n...

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Detalhes bibliográficos
Autor principal: Agostinho, Paula (author)
Outros Autores: Lopes, João P. (author), Velez, Zélia (author), Oliveira, Catarina R. (author)
Formato: article
Idioma:eng
Publicado em: 2008
Assuntos:
Texto completo:http://hdl.handle.net/10316/4680
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/4680