Development of stimuli-responsive smart hydrogels using molecular imprinting and interpenetrating polymer networks

Different classes of stimuli-responsive smart hydrogels (SRSH) were synthesized in order to assess the usefulness of molecular imprinting and generation of interpenetrating polymer networks to obtain advanced materials with tailored properties/performance. Reversible Addition-Fragmentation Chain-Tra...

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Detalhes bibliográficos
Autor principal: Oliveira, Tânia (author)
Outros Autores: Reitor, Patrícia (author), Oliveira, Daniela (author), Kadhirvel, Porkodi (author), Dias, Rolando (author), Costa, Mário Rui (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2014
Assuntos:
Molecular imprinting
Interpenetrating polymers
Stimuli-responsive
Hydrogels
Texto completo:http://hdl.handle.net/10198/10427
País:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/10427
Descrição
Resumo:Different classes of stimuli-responsive smart hydrogels (SRSH) were synthesized in order to assess the usefulness of molecular imprinting and generation of interpenetrating polymer networks to obtain advanced materials with tailored properties/performance. Reversible Addition-Fragmentation Chain-Transfer (RAFT) polymerisation was exploited as an additional tool to increase the control on the formation process of these materials. Batch adsorption and frontal analysis (e.g. for 3-aminopyridine (3AMP) as depicted in the graphical abstract) techniques were used to quantify the affinity of different drugs with the produced SRSH. Stimulated drug release (e.g. due to temperature/pH changes) and protein immobilisation/release were also tested. Results obtained show that molecular imprinting and generation of interpenetrating networks are effective routes to obtain tailored materials with a particular affinity to selected template molecules.

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