The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver...

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Bibliographic Details
Main Author: Rossato, Luciana Grazziotin (author)
Other Authors: Costa, Vera Marisa (author), Pinho, Paula Guedes de (author), Arbo, Marcelo Dutra (author), Freitas, Vítor de (author), Vilain, Laure (author), Bastos, Maria de Lourdes (author), Palmeira, C. M. (author), Remião, Fernando (author)
Format: article
Language:eng
Published: 2013
Subjects:
Mitoxantrone
Metabolism
Bioactivation
LC/MS
S9 fraction
Cardiotoxicity
Online Access:http://hdl.handle.net/10316/25667
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25667

Internet

http://hdl.handle.net/10316/25667

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