The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver...

ver descrição completa

Detalhes bibliográficos
Autor principal: Rossato, Luciana Grazziotin (author)
Outros Autores: Costa, Vera Marisa (author), Pinho, Paula Guedes de (author), Arbo, Marcelo Dutra (author), Freitas, Vítor de (author), Vilain, Laure (author), Bastos, Maria de Lourdes (author), Palmeira, C. M. (author), Remião, Fernando (author)
Formato: article
Idioma:eng
Publicado em: 2013
Assuntos:
Mitoxantrone
Metabolism
Bioactivation
LC/MS
S9 fraction
Cardiotoxicity
Texto completo:http://hdl.handle.net/10316/25667
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25667

Texto Completo

http://hdl.handle.net/10316/25667

Registos relacionados