VCAM1, HMOX1 and NOS3 differential endothelial expression may impact sickle cell anemia vasculopathy

Endothelial dysfunction plays a major role in sickle cell anemia (SCA) systemic vasculopathy, with upregulation of adhesion molecules (e.g., VCAM-1), decreased nitric oxide bioavailability, and oxidative stress. We aimed to assess the modulation role of pro-inflammatory and pro-oxidative stimuli on...

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Detalhes bibliográficos
Autor principal: Silva, Marisa (author)
Outros Autores: Coelho, Andreia (author), Sofia, Vargas (author), Faustino, Paula (author)
Formato: article
Idioma:eng
Publicado em: 2022
Assuntos:
Sickle Cell Anemia
Heme
Hydroxyurea
Vascular Endothelium
VCAM1
TNF-α
VCAM1 Promoter Haplotypes
Hidroxyurea
Anemia das Células Falciformes
Doença vascular
Modificadores genéticos
Doenças Genéticas
Drepanocitose
Texto completo:http://hdl.handle.net/10400.18/7892
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7892

Texto Completo

http://hdl.handle.net/10400.18/7892

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