VCAM1, HMOX1 and NOS3 differential endothelial expression may impact sickle cell anemia vasculopathy

Endothelial dysfunction plays a major role in sickle cell anemia (SCA) systemic vasculopathy, with upregulation of adhesion molecules (e.g., VCAM-1), decreased nitric oxide bioavailability, and oxidative stress. We aimed to assess the modulation role of pro-inflammatory and pro-oxidative stimuli on...

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Bibliographic Details
Main Author: Silva, Marisa (author)
Other Authors: Coelho, Andreia (author), Sofia, Vargas (author), Faustino, Paula (author)
Format: article
Language:eng
Published: 2022
Subjects:
Sickle Cell Anemia
Heme
Hydroxyurea
Vascular Endothelium
VCAM1
TNF-α
VCAM1 Promoter Haplotypes
Hidroxyurea
Anemia das Células Falciformes
Doença vascular
Modificadores genéticos
Doenças Genéticas
Drepanocitose
Online Access:http://hdl.handle.net/10400.18/7892
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7892

Internet

http://hdl.handle.net/10400.18/7892

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