Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca2+ channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the...

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Detalhes bibliográficos
Autor principal: Yoshiba, Satoko (author)
Outros Autores: Shiratori, Hidetaka (author), Kuo, Ivana Y. (author), Kawasumi, Aiko (author), Shinohara, Kyosuke (author), Nonaka, Shigenori (author), Asai, Yasuko (author), Sasaki, Genta (author), Belo, José A. (author), Sasaki, Hiroshi (author), Nakai, Junichi (author), Dworniczak, Bernd (author), Ehrlich, Barbara E. (author), Pennekamp, Petra (author), Hamada, Hiroshi (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Polycystic kidney disease
Left-right asymmetry
Left-right axis
Mice
Channel
Protein
Expression
Release
Lacking
Kif3A
Texto completo:http://hdl.handle.net/10400.1/11866
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11866

Texto Completo

http://hdl.handle.net/10400.1/11866

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