Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca2+ channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the...

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Bibliographic Details
Main Author: Yoshiba, Satoko (author)
Other Authors: Shiratori, Hidetaka (author), Kuo, Ivana Y. (author), Kawasumi, Aiko (author), Shinohara, Kyosuke (author), Nonaka, Shigenori (author), Asai, Yasuko (author), Sasaki, Genta (author), Belo, José A. (author), Sasaki, Hiroshi (author), Nakai, Junichi (author), Dworniczak, Bernd (author), Ehrlich, Barbara E. (author), Pennekamp, Petra (author), Hamada, Hiroshi (author)
Format: article
Language:eng
Published: 2018
Subjects:
Polycystic kidney disease
Left-right asymmetry
Left-right axis
Mice
Channel
Protein
Expression
Release
Lacking
Kif3A
Online Access:http://hdl.handle.net/10400.1/11866
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11866

Internet

http://hdl.handle.net/10400.1/11866

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