Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of hum...

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Detalhes bibliográficos
Autor principal: Marteil, G (author)
Outros Autores: Guerrero, A (author), Vieira, AF (author), Almeida, B (author), Machado, P (author), Mendonça, S (author), Mesquita, M (author), Villarreal, B (author), Fonseca, I (author), Francia, M (author), Dores, K (author), Martins, N (author), Jana, S (author), Tranfield, E (author), Barbosa-Morais, N (author), Paredes, J (author), Pellman, D (author), Godinho, S (author), Bettencourt-Dias, M (author)
Formato: article
Idioma:eng
Publicado em: 2018
Texto completo:https://hdl.handle.net/10216/127072
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/127072

Texto Completo

https://hdl.handle.net/10216/127072

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