Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of hum...

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Bibliographic Details
Main Author: Marteil, G (author)
Other Authors: Guerrero, A (author), Vieira, AF (author), Almeida, B (author), Machado, P (author), Mendonça, S (author), Mesquita, M (author), Villarreal, B (author), Fonseca, I (author), Francia, M (author), Dores, K (author), Martins, N (author), Jana, S (author), Tranfield, E (author), Barbosa-Morais, N (author), Paredes, J (author), Pellman, D (author), Godinho, S (author), Bettencourt-Dias, M (author)
Format: article
Language:eng
Published: 2018
Online Access:https://hdl.handle.net/10216/127072
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/127072

Internet

https://hdl.handle.net/10216/127072

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