Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here identify the voltage-dependent anion channels VDAC1...

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Detalhes bibliográficos
Autor principal: Dadsena, Shashank (author)
Outros Autores: Bockelmann, Svenja (author), Mina, John G.M. (author), Hassan, Dina G. (author), Korneev, Sergei (author), Razzera, Guilherme (author), Jahn, Helene (author), Niekamp, Patrick (author), Müller, Dagmar (author), Schneider, Markus (author), Tafesse, Fikadu G. (author), Marrink, Siewert J. (author), Melo, Manuel N. (author), Holthuis, Joost C.M. (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
SDG 3 - Good Health and Well-being
Texto completo:http://hdl.handle.net/10362/92533
País:Portugal
Oai:oai:run.unl.pt:10362/92533

Texto Completo

http://hdl.handle.net/10362/92533

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