Listeria monocytogenes induces host DNA damage and delays the host cell cycle to promote infection

Listeria monocytogenes (Lm) is a human intracellular pathogen widely used to uncover the mechanisms evolved by pathogens to establish infection. However, its capacity to perturb the host cell cycle was never reported. We show that Lm infection affects the host cell cycle progression, increasing its...

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Bibliographic Details
Main Author: Leitão, E (author)
Other Authors: Costa, AC (author), Brito, C (author), Costa, L (author), Pombinho, R (author), Cabanes, D (author), Sousa, S (author)
Format: article
Language:eng
Published: 2014
Subjects:
Calcium-Binding Proteins/metabolism
Cell Cycle/physiology
Cell Line, Tumor
DNA Breaks
DNA Damage
DNA Repair
DNA Replication
Host-Pathogen Interactions
Humans
Listeria monocytogenes/physiology
Listeriosis/metabolism
Listeriosis/microbiology
Listeriosis/pathology
S Phase
cdc25 Phosphatases/metabolism
Online Access:http://hdl.handle.net/10216/114485
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114485

Internet

http://hdl.handle.net/10216/114485

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