PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were fun...

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Bibliographic Details
Main Author: Santos, Sofia D. (author)
Other Authors: Xavier, Miguel (author), Leite, Diana M. (author), Moreira, Débora A. (author), Custódio, Beatriz (author), Torrado, Marília (author), Castro, Rita (author), Leiro, Victoria (author), Rodrigues, João (author), Tomás, Helena (author), Pêgo, Ana P. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Dendrimers
Dendrimers Poly(amidoamine) PAMAM
Poly(ethyleneglycol) PEG
Nanomaterials
Nanomedicine
Drug delivery
Blood-brainbarrier
Brainischemia
Stroke
In vivo
.
Faculdade de Ciências Exatas e da Engenharia
Online Access:http://hdl.handle.net/10400.13/2441
Country:Portugal
Oai:oai:digituma.uma.pt:10400.13/2441

Internet

http://hdl.handle.net/10400.13/2441

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