PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were fun...

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Detalhes bibliográficos
Autor principal: Santos, Sofia D. (author)
Outros Autores: Xavier, Miguel (author), Leite, Diana M. (author), Moreira, Débora A. (author), Custódio, Beatriz (author), Torrado, Marília (author), Castro, Rita (author), Leiro, Victoria (author), Rodrigues, João (author), Tomás, Helena (author), Pêgo, Ana P. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Dendrimers
Dendrimers Poly(amidoamine) PAMAM
Poly(ethyleneglycol) PEG
Nanomaterials
Nanomedicine
Drug delivery
Blood-brainbarrier
Brainischemia
Stroke
In vivo
.
Faculdade de Ciências Exatas e da Engenharia
Texto completo:http://hdl.handle.net/10400.13/2441
País:Portugal
Oai:oai:digituma.uma.pt:10400.13/2441

Texto Completo

http://hdl.handle.net/10400.13/2441

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