A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins

Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for a full p53 reactivation, represents a...

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Bibliographic Details
Main Author: Joana Soares (author)
Other Authors: Liliana Raimundo (author), Nuno A L Pereira (author), Daniel J V A dos Santos (author), Maria Perez (author), Gloria Queiroz (author), Mariana Leao (author), Maria M M Santos (author), Lucilia Saraiva (author)
Format: article
Language:eng
Published: 2015
Subjects:
Medicina básica
Basic medicine
Online Access:https://repositorio-aberto.up.pt/handle/10216/94241
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/94241

Internet

https://repositorio-aberto.up.pt/handle/10216/94241

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