Fine time scaling of purifying selection on human nonsynonymous mtDNA mutations based on the worldwide population tree and mother-child pairs

A high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large popul...

Full description

Bibliographic Details
Main Author: Cavadas, Bruno (author)
Other Authors: Soares, Pedro (author), Camacho, Rui (author), Brandão, Andreia (author), Costa, Marta D (author), Fernandes, Verónica (author), Pereira, Joana B (author), Rito, Teresa S (author), Samuels, David C (author), Pereira, Luisa (author)
Format: article
Language:eng
Published: 2015
Subjects:
mtDNA
Worldwide phylogenetic tree
Mother–child pairs
Massive parallel sequencing
Heteroplasmy
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/40675
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40675

Internet

http://hdl.handle.net/1822/40675

Similar Items