Monitoring Abacavir Bioactivation in Humans: Screening for an Aldehyde Metabolite

The anti-HIV drug abacavir is associated with idiosyncratic hypersensitivity reactions and cardiotoxicity. Although the mechanism underlying abacavir-toxicity is not fully understood, drug bioactivation to reactive metabolites may be involved. This work was aimed at identifying abacavir-protein addu...

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Bibliographic Details
Main Author: Grilo, N (author)
Other Authors: Antunes, A (author), Caixas, U (author), Marinho, A (author), Charneira, C (author), Oliveira, MC (author), Monteiro, E (author), Marques, MM (author), Pereira, S (author)
Format: article
Language:eng
Published: 2014
Subjects:
CHLC MED
Aldeídos
Marcadores Biológicos
Biotransformação
Didesoxinucleosídeos
Monitorização de Medicamentos
Hemoglobinas
Proteínas
Espectrometria de Massas por Ionização por Electrospray
Anti-Retrovirais
Infecção por HIV
Espectrometria de Massas em Tandem
Metabolismo
Efeitos Adversos
Online Access:http://hdl.handle.net/10400.17/1774
Country:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/1774

Internet

http://hdl.handle.net/10400.17/1774

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