Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus were synthesized and evaluated as potential transmission-blocking antimalarial prodrugs. All compounds were hydrolyzed to the parent dipeptide derivative of primaquine in neutral and basic solutions, with half li...

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Bibliographic Details
Main Author: Vale, Nuno (author)
Other Authors: Nogueira, Fatima (author), do Rosario, Virgilio E. (author), Gomes, Paula (author), Moreira, Rui (author)
Format: article
Language:eng
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10451/21520
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21520